New research suggests that individuals who come off popular slimming jabs like Mounjaro or Wegovy can put back on reduced body mass at a significantly accelerated pace than those who stop conventional lifestyle plans.
Research printed in a major health publication shows that while obese people often shed a large proportion of their total mass while on the medication, the mass comes back at an average rate of nearly a kilo each month upon discontinuation.
"Users using such treatments need to be cognizant of the danger of rapid weight regain when the therapy is stopped," stated expert Dr. Susan Jebb.
This pace of recovery suggests a return to original weight within about one and a half years.
Comparing Treatments
The study, which examined dozens of studies involving thousands of participants, compared the results of these new drugs with other pills.
Scientists emphasize that people who shed pounds through dieting usually see a less rapid weight regain—approximately 0.1 kg a month—post-intervention.
The Reason for the Rapid Regain
Nutrition scientists believe the mode of action of the injections accounts for the accelerated rebound.
The injections imitate a natural hormone called GLP-1, which helps regulate appetite.
"Artificially providing the hormone levels far above than normal could lead to the body to produce less of its endogenous GLP-1, and may also reduce responsiveness to its effects," noted Dr. Adam Collins, a dietetics expert.
"Discontinuation of this GLP-1 'fix' leads to appetite is unsuppressed, making binge eating a significant risk."
A Chronic Issue?
The NHS suggest the injections for people with obesity-related medical conditions, alongside recommended lifestyle changes.
Many experts say that, due to the likelihood of relapse, the treatment might need to be life-long.
This view is supported by drug manufacturers, who say that the results "emphasize the persistent character of obesity," akin to managing conditions like diabetes.
Patient Testimonies
People who have discontinued the jabs explain a sudden resurgence of hunger.
"It was like a switch that goes on and I was suddenly starving," recalled an individual.
This challenge is compounded if users have not developed lasting lifestyle or habit changes during treatment.
Widespread Adoption
Survey data indicate that a significant number of people in the UK have tried weight-loss jabs in the last 12 months, with demand continuing to grow.
- Adoption is higher among females than males.
- The middle-aged age group shows the highest usage rates.
- A large proportion obtain the medications through private healthcare rather than public health services.
Ultimately, researchers emphasize that while these medications are effective agents for shedding pounds, they are not a standalone solution and maintained weight loss relies on integrated lifestyle changes.
